PATHOGENESIS OF MICROCIRCULATION DISORDERS IN DIABETIC PATIENTS AND THERAPEUTIC APPROACHES

Authors

  • Iskandarov Doniyor Boxodirovich Republican Specialized Scientific and Practical Medical Center of Endocrinology, Fergana Branch Author

Keywords:

diabetes mellitus, microcirculation disorders, diabetic microangiopathy, endothelial dysfunction, advanced glycation end products, oxidative stress, basement membrane thickening, autoregulation impairment, therapeutic intervention

Abstract

This thesis examines microcirculation disorders in diabetes mellitus and modern strategies to correct them. It reviews molecular, cellular, and hemodynamic changes in diabetic microangiopathy, focusing on endothelial dysfunction, basement membrane thickening, and impaired autoregulation. Key factors include hyperglycemia-induced oxidative stress, advanced glycation products, and inflammation. Therapies like glycemic control, antioxidants, and targeted drugs show potential for restoring microcirculation. The study offers a clear framework for understanding and managing diabetic microvascular complications.

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Published

2025-07-25

Issue

2025: ICMSE-27th July

Section

Articles

How to Cite

PATHOGENESIS OF MICROCIRCULATION DISORDERS IN DIABETIC PATIENTS AND THERAPEUTIC APPROACHES. (2025). International Conference on Multidisciplinary Sciences and Educational Practices, 35-37. https://econfseries.com/index.php/7/article/view/2528