COMPARATIVE ANALYSIS OF MORPHOLOGICAL FEATURES OF THE SPLEEN IN LATE POSTNATAL ONTOGENESIS UNDER NICOTINE-ALCOHOL INTOXICATION AND AFTER THERAPEUTIC CORRECTION

Abstract

This study presents the results of a comparative morphological evaluation of the spleen during late postnatal ontogenesis under the influence of chronic nicotine-alcohol intoxication and subsequent therapeutic intervention. Structural alterations in the parenchyma and stroma of the spleen were identified under toxic stress, as well as the efficacy of corrective treatment based on hepatoprotective and antioxidant agents. Histological and morphometric techniques were used to objectively assess the severity of pathological changes and the extent of tissue regeneration.