THE ROLE OF ENDOPLASMIC RETICULUM STRESS IN THE RELATIONSHIP BETWEEN METABOLIC SYNDROME AND LEPTIN RESISTANCE IN WOMEN

Authors

  • Isaqjonova Moxinur Nodirjon qizi Endocrinologist, family polyclinic No. 4, Fergana city, Fergana region Author

Keywords:

endoplasmic reticulum stress, leptin resistance, metabolic syndrome, obesity, unfolded protein response (UPR), inflammation, adipose tissue, hypothalamus, women, estrogen, insulin resistance, metabolic dysfunction,

Abstract

Metabolic syndrome in women is frequently accompanied by leptin resistance, yet the underlying cellular mechanisms remain incompletely understood. This study examines how endoplasmic reticulum (ER) stress contributes to impaired leptin signaling in female patients with metabolic syndrome. We investigate the activation of ER stress markers including GRP78, XBP1, and CHOP, and their impact on leptin receptor function and downstream signaling pathways, proposing ER stress modulation as a potential therapeutic target.

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Published

2025-10-30

Issue

ICMSMP-30th OCTOBER, 2025

Section

Articles

How to Cite

THE ROLE OF ENDOPLASMIC RETICULUM STRESS IN THE RELATIONSHIP BETWEEN METABOLIC SYNDROME AND LEPTIN RESISTANCE IN WOMEN. (2025). International Conference on Medical Science, Medicine and Public Health, 277-279. https://econfseries.com/index.php/8/article/view/3309