INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION IN THE PATHOGENESIS OF DIABETES MELLITUS

Authors

  • Axunbayev Otabek Adilovich Assistant of the Department of Endocrinology and Radiology, Fergana Medical Institute of Public Health Author

Keywords:

beta-cell dysfunction, glucose homeostasis, hyperinsulinemia, pancreatic islets, insulin signaling pathway, metabolic syndrome, glucotoxicity, lipotoxicity, beta-cell mass

Abstract

This study explores the complex interaction between insulin resistance and pancreatic beta-cell dysfunction in the pathogenesis of type 2 diabetes mellitus. It highlights how impaired insulin sensitivity and declining beta-cell function mutually reinforce each other, leading to progressive metabolic failure. The findings offer a clearer understanding of diabetes progression and inform strategies for early diagnosis and targeted treatment.

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Published

2025-10-30

Issue

ICMSMP-30th OCTOBER, 2025

Section

Articles

How to Cite

INSULIN RESISTANCE AND BETA-CELL DYSFUNCTION IN THE PATHOGENESIS OF DIABETES MELLITUS. (2025). International Conference on Medical Science, Medicine and Public Health, 287-289. https://econfseries.com/index.php/8/article/view/3313