THE PROBLEM OF ANTIBIOTIC RESISTANCE IN CHILDREN

Abstract

This thesis explores the epidemiological trends, molecular mechanisms, and treatment strategies related to antimicrobial resistance in children. Although pediatric mortality from resistant infections has declined by over 50% since 1990, the rise of extended-spectrum beta-lactamase producers and multidrug-resistant pathogens remains a major concern. Contributing factors include poor infection control, inappropriate antibiotic use, and limited diagnostic resources in pediatric care. Resistant bacterial infections still cause around 200,000 child deaths globally each year, underscoring the urgent need for improved antimicrobial stewardship, robust surveillance, and innovative therapies.