MORPHOLOGICAL CHANGES IN THE WALL OF THE SMALL INTESTINE IN EXPERIMENTAL 3-MONTH-OLD WHITE BREED RATS WITH BURNS OF THE DIGESTIVE TRACT CAUSED BY ACETIC ACID

Abstract

Acetic acid has a local cauterizing effect by the type of coagulation necrosis and a pronounced resorptive hemato -, nephro - and hepatotoxic effect due to hemolysis of erythrocytes, the development of toxic coagulopathy, syndrome of disseminated intravascular coagulation. Tissue damage is caused by a violation of cell membranes as a result of the dissolution of lipids, which make up their main structural unit. The formation of acidic radicals stimulates the peroxidation of membranes and exacerbates the process of cell destruction. The cauterizing effect is most pronounced in the respiratory tract and in the gastrointestinal tract.