PROGNOSTIC SIGNIFICANCE OF BIOLOGICAL SUBTYPE FOR CHOICE OF SURGICAL TREATMENT TACTICS IN EARLY BREAST CANCER

Abstract

Breast cancer (BC) is one of the most common oncological diseases in the world, with about 1.7 million cases diagnosed annually [1,3]. In the structure of oncological morbidity among the female population, BC ranks first in most economically developed countries; this oncological pathology occupies a leading position both in the structure of malignant neoplasm morbidity among the female population (21.2%) and in the mortality structure [5]. Breast cancer is a heterogeneous tumor, the course and treatment options of which are determined primarily by biological characteristics: the presence of steroid hormone receptors, Her2\ neu expression , proliferation index, as well as the prevalence of the process, age and functional status of the ovaries. The established clinical concepts of the course of the disease made it possible to create a biological classification of BC used to individualize the choice of treatment tactics for patients [2,4] . The development of diagnostic methods and more advanced treatment methods, the systematic use of adjuvant therapy, and the introduction of new, more effective antitumor drugs have significantly improved the treatment results for patients with breast cancer, especially in patients with its early forms.