THE ROLE OF NEOROTRANSMITTERS IN PAIN AND ITS MANAGEMENT IN THE BODY

Abstract

Pain is a complex experience. It is comprised of dynamic interactions between physical, cognitive, spiritual, emotional, and environmental factors and cannot be characterized as only a response to injury. The International Association for the Study of Pain and the American Pain Society defined pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.” Pain modulation involves many different mechanisms that increase or decrease the transmission of pain signals throughout the nervous system. Depending on the mechanism, modulation can occur before, during, or after pain is perceived.